Best Immune System Support Supplements: My Top 3 for 2022

Last Updated on February 18, 2022 by Monica Nelson

Check out this post for an in-depth look at the best immune system support supplements that money can buy!

Immune support is something that we often neglect in the hustle and bustle of day-to-day life. It’s not until a cold or flu hits us when we realize how important immune health truly is.

Making sure you are taking care of your immune system with the right supplements can make all the difference in preventing illness and keeping you healthy throughout the year.

That’s exactly why I made this guide for some of my favorite immune support supplements that you can get your hands on today.

So, with no further ado, let’s get into this!

Best Immune Support Supplements: Top 3 for 2022

Performance Lab PL-Immune



  • Helps restore and strengthen your immune system
  • Combats shortfalls due to stress, toxins, and over-training
  • Activates your immune cells so they can work more efficiently


  • Combines NutriGenesis® Vitamin D, Vitamin C, Zinc & Selenium to restore foundational immune support
  • Unique probiotic LC-Plasma (IMMUSE™) activates five types of immune cells
  • 100% plant-based NutriCaps® made from pullulan (fermented tapioca), infused with prebiotics for enhanced absorption and digestive comfort.

Read my full Performance Lab PL-Immune Review

Product Overview

Our immune systems are designed to protect us from disease and infection, but several factors can weaken them.

Stress, toxins, vitamin & mineral deficiencies, and over-training all play a role in weakening our immune system. When this happens, we’re more susceptible to illness and injury. 

Luckily, Performance Lab PL-Immune provides broad-spectrum support for the body’s natural defense mechanisms, restoring weakened defenses and protecting against pathogens to fight off infections and improve your overall health and wellbeing.

That’s precisely the reason it’s my number 1 choice when it comes to the best immune system support supplements. So, what are you waiting for – order yours now!

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Performance Lab NutriGenesis® Multi for Women

NutriGenesis® Multi for Women


  • Calibrated explicitly to the nutritional needs of women
  • Whole-food cofactors for optimal absorption
  • Supplies at least 100% daily value of 17+ essential vitamins and minerals
  • Bridges any nutrient gaps that may exist in your diet


  • Nature-identical NutriGenesis® vitamins and minerals with no synthetic or isolated nutrients
  • Foundational nutritional support for healthy whole-body biological performance
  • Prebiotic-infused, vegan-friendly NutriCaps® for optimal comfort and nutrient absorption.

Product Overview

Performance Lab® NutriGenesis® Multi is a premium, high-performance, and vegan-friendly multivitamin for women that supports healthy cell performance across all body systems.

It’s made with the latest in nutritional technology and delivers 100%+ DV of 17+ essentials—all in NutriCaps®, prebiotic-infused, and vegan-friendly for digestive comfort and peace of mind.

Forget about generic multivitamin products that claim to provide your daily essentials in optimal amounts and choose the gender-specific NutriGenesis® Multi for Women instead!

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Performance Lab Prebiotic



  • Supports your existing probiotics
  • Reliable, natural, and comfortable microbiome support
  • Promotes healthy immune function in the GI tract
  • Supports bone and heart health by enhancing calcium absorption and regulating bad cholesterol absorption


  • Orafti® Synergy1: Oligofructose-enriched inulin (Inulin-FOS) from chicory root
  • 100% natural, vegan-friendly, prebiotic-infused NutriCaps® from pullulan (fermented tapioca)

Product Overview

Probiotic supplements seem to be all the rage these days when it comes to gut health.

The problem is that most of them fail to deliver on their promise of microbiome support because their live cultures overload the gut and can even cause gastric distress.

That’s where Performance Lab Prebiotic comes in; a natural prebiotic fiber supplement that feeds your existing probiotics – delivering more reliable, natural, and comfortable microbiome support for better digestive health, immune function, fat loss, and more!

If you’re searching for a prebiotic supplement, why settle for a mediocre one? Get your hands on Performance Lab Prebiotic today!

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How Does The Immune System Work?

The immune system is one of the first lines of defense that our body has against illness. And when it’s functioning well, the immune system helps to keep us healthy and able to fend off any infection.

Immune cells in the body are effectively soldiers that go on a patrol to look for invaders in your body.

When there’s an intruder, the immune cells send chemical signals to each other and then release dangerous chemicals like free radicals to fight off whatever is attacking you.

But sometimes, your immune system can be compromised, whether it’s because of an inherited condition or an infection.

Factors such as smoking, alcohol consumption, stress, and lack of sleep are also major contributory factors when it comes to poor immunity.

Fostering a healthy lifestyle will go a long way in keeping your immune system strong! But your body could always do with a helping hand, which is where an immune support supplement can play a vital role.

But do they really work? Or are immune support supplements a waste of money? Read on to find out!

Can Supplements Help Your Immunity?

If you’re someone who cares about keeping themselves healthy, you may be wondering if immune support supplements can make a difference. With that in mind, it’s safe to say that they come in useful for helping to ward off illness or support the immune system in challenging times.

However, supplements to help with immunity are not a substitute for regular exercise and good diet habits; you should use them in conjunction with healthy lifestyle choices to ensure you make the most out of them.

Supplements can be helpful if someone already has an underlying condition that is compromising their immunity.

But always remember to use supplements alongside a healthy diet and frequent exercise instead of relying on them solely to boost your immune system!

Top 5 Immune-Boosting Vitamins and Minerals

Vitamin C

Vitamin C is one of the most critical immune-boosting vitamins as it is needed to produce immune system cells. It also helps maintain healthy skin, bones, and teeth by maintaining collagen levels in the body.

Vitamin C is found naturally in fruits like oranges and kiwi fruit but can be consumed as a supplement if you don’t eat enough whole foods containing it.

Vitamin D

When it comes to boosting your immunity, vitamin D may be the most powerful nutrients around. Your immune system needs vitamin D to produce a protein called cathelicidin, which plays an important role in protecting your body against infections like colds and the flu.

Vitamin D also helps regulate the immune system’s response to disease and infection, making it a vital nutrient to keep your immune system functioning the way it should.

Vitamin A

In the body, there are two forms of Vitamin A: preformed and plant-based. Preformed is found in animal foods such as fish, meat, and dairy, making them important sources for this nutrient.

Plant carotenoids can also be converted to Vitamin A, which provides a more balanced diet without harmful side effects like those that come with eating too much red meat or drinking milk products from animals raised on factory farms.

The human body needs certain nutrients like vitamin A to stay healthy, so it’s vital that you get enough each day to help keep your immune system in top shape.

Vitamin E

Vitamin E is a potent antioxidant that helps fight inflammation. It can help reduce the duration of colds and flu.

Vitamin E acts as an immune system booster since it plays a key role in nearly 200 biochemical reactions happening inside our bodies, a marker of its importance in the diet.

High-fat plant-food sources such as almonds, avocados, peanuts/peanut butter are all great sources of vitamin E, so it’s a good idea to include plenty of these foods in your diet to keep your E levels topped up.


Zinc is an essential mineral that the immune system needs to function properly since it controls inflammation. It also boosts your body’s immune response by stimulating the production of inflammatory proteins and antibodies.

Top food sources of zinc include oysters, beef liver, pumpkin seeds, cashews, yogurt, and sunflower seeds.

However, research shows that billions of people across the globe suffer from a zinc deficiency. To ensure that you don’t fall under this category, you must get enough zinc daily through your diet, supplementation, or a combination of the two.


Selenium is a necessary mineral to have for the immune system to function properly. If you don’t get enough selenium, your body will be more prone to infection.

Animal sources of food are best because they offer an abundance of this nutrient. Brazil nuts are also very high in selenium, making them an excellent choice for those on a plant-based diet looking to increase their intake of this mineral.

However, be sure not to consume too much selenium daily, as you may experience unwanted side effects such as muscle tenderness, tremor, lightheadedness, facial flushing, nausea, loss of energy, and irritability.

Conclusion – Best Immune System Support Supplements 2022

The best way to ensure that your immune system is functioning at its peak so you can stay healthy during cold and flu season, or any other time of the year for that matter, is by making healthy lifestyle choices.

Eating a nutritious diet rich in fruits and vegetables every day while getting plenty of exercise will give your body everything it needs to ward off infection naturally without relying on supplements.

At the same time, however, there are some instances where an extra boost may be needed, such as when you’re recovering from illness or if you have certain conditions that suppress your immunity.

That’s where immune system support supplements come in!

I’m not saying you should see them as a replacement for living healthily; it’s instead something that can enhance your efforts.

But as long as you understand the importance of making healthy lifestyle choices, immune system support supplements such as the ones I’ve recommended above can make a huge difference.

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